EurekAlert!

BRCA1 gene mutations may not be key to prostate cancer initiation, as previously thought

Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic) might not be key to the initiation of prostate cancer, as previously thought, suggests the first study of its ...
News Medical

Study challenges role of BRCA1 mutation in prostate cancer initiation

These revealed 27 germline BRCA2 variants (6%), but only 2 germline BRCA1 variants (0.5%), and one of these probably wasn't the driver as an ATM mutation was also present, note the researchers. Six ...
ascopubs.org

Germline mutations and the presence of clonal hematopoiesis of indeterminate potential (CHIP) in 20,963 patients with BRCA-associated cancers.

Real-world performance of a multi-cancer early detection test based on integrative analysis of cell-free DNA whole-methylome sequencing. This is an ASCO Meeting Abstract from the 2023 ASCO Annual ...
ascopubs.org

Implementation of Universal Germline Genetic Testing Into Standard of Care for Patients With Prostate Cancer: The Time Is Now

Indications for and implications of germline genetic testing (GGT) in patients with prostate cancer have expanded over the past decade, particularly related to precision therapies and management. GGT ...
Medscape

Germline Testing In Advanced Cancer Can Lead to Targeted Tx

From 7% to nearly 9% of patients with advanced cancer were found to harbor a germline variant with targeted therapeutic actionability in the first study of its kind. The study involved 11,974 patients ...