Axonal damage causes neurological defects in multiple sclerosis. In vivo imaging in mouse models of multiple sclerosis now shows a reversible and sequential process of focal axonal degeneration (FAD) ...

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Researchers at VIB and KU Leuven have identified a molecular process that allows motor neurons to maintain protein production, a process that fails in amyotrophic lateral sclerosis (ALS). The study, ...

Local mRNA translation is a post-transcriptional gene regulatory mechanism that enables autonomous control of local proteomes in subcellular compartments. This mechanism operates in neuronal dendrites ...

Study unveils mechanisms driving axonal accumulation of TDP-43 and associated nerve damage in ALS by Ingrid Fadelli, Medical Xpress edited by Sadie Harley, reviewed by Robert Egan ...

What is an Diffuse Axonal Injury? A diffuse axonal injury is an injury in which the wires which connect the cells in the brain, get damaged. If you rapidly accelerate and then decelerate the head, the ...

Columbia neuroscientists have discovered why mitochondria, tiny power generators that keep our cells healthy, are often strangely shaped inside the brain. Mitochondria, which exist by the thousands in ...

Absolutely. The electrophysiologic characteristics of neuronopathies and axonopathies depend on how long the condition has been present. In the acute states, there is moderate-to-severe denervation, ...

Researchers from the Icahn School of Medicine at Mount Sinai have discovered a molecular switch in neurons that limits the regrowth of damaged axonal fibers. The ...