Eukaryotic DNA replication relies on a highly orchestrated series of events centred on the Cdc45–MCM–GINS (CMG) helicase complex. Origin licensing begins in G1 phase with loading of a double hexamer ...
Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by ...
DNA replication in eukaryotes is a highly orchestrated process that ensures precise genome duplication before cell division. Initiation occurs at multiple replication origins that are licensed in G1 ...
Illustration of fork-MMEJ and BIR pathways in repairing single-ended DNA double-stranded breaks at broken replication forks, highlighting ATR-mediated regulation of the transition between these two ...
A cancer drug target already being investigated in clinical trials turns out to be doing something even more consequential than researchers realized. Scientists at Scripps Research have discovered ...
DNA repair mechanism: HELQ helicase remodels stalled replication forks into stable structures, preventing harmful mutations under replication stress. Advanced imaging tool: RF-SIRF maps reversed forks ...
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