Targeting of CD28 and CD38 as a potential novel therapeutic strategy for peripheral T-cell lymphomas
The identification of new targets and therapeutic strategies for peripheral T-cell lymphomas (PTCLs), which often have an aggressive clinical course, is needed. Bi and trispecific antibodies allowing ...
T cells genetically modified to express a chimeric antigen receptor (CAR) has shown tremendous potential against a variety of hematological malignancies 1,2. Despite the clinical success, a ...
Efficient T-cell engineering is crucial for the success of CAR T-cell therapy research, but it requires multiple labor-intensive steps, including T-cell isolation, activation, and transduction.
Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the immune system. St. Jude Children's Research Hospital scientists recently ...
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