CTCF is widely recognized for its essential role in mediating chromatin loops to regulate gene expression, particularly by modulating enhancer-promoter (EP) interactions. However, acute depletion of ...
In a recent study published in the journal Nucleic Acids Research, researchers investigate whether machine learning can identify pan-cancer mutational hotspots at persistent CCCTC-binding factor ...
Biology is never as straightforward as we learned in high school. Take sex-linked chromosomes as an example: we’re taught that biological males get XY chromosomes while biological females get two ...
Glioblastoma (GBM) is one of the most common and aggressive primary brain tumors in adults, carrying an extremely poor ...
Studying the spatial landscape of the genome can bring new insights into our understanding of the disease developments. Multiple methods of capturing the spatial landscape were introduced from 2002, ...
“This is the first detailed study of how and where ORC regulates epigenetics and gene expression in human cells,” said Anindya Dutta, Ph.D., leader of the study and chair of the University of Alabama ...
Heat shock induces alternative polyadenylation through dynamic DNA methylation and chromatin looping
Alternative cleavage and polyadenylation (APA) is a gene regulatory mechanism used by cells under stress to upregulate proteostasis-promoting transcripts, but how cells achieve this remains poorly ...
Research has uncovered a previously unknown, widespread role of ORC in regulating human cell gene expression. New work has revealed a much wider role for origin-recognition complex (ORC) in regulating ...
Origin-recognition complex, or ORC, plays an unexpectedly broad role in the regulation of human cell gene expression, according to a study in the journal Cell Reports. This is the first detailed study ...
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