Nature

CYP3A4 overexpression enhances apoptosis induced by anticancer agent imidazoacridinone C-1311, but does not change the metabolism of C-1311 in CHO cells

To examine whether CYP3A4 overexpression influences the metabolism of anticancer agent imidazoacridinone C-1311 in CHO cells and the responses of the cells to C-1311. Wild type CHO cells (CHO-WT), CHO ...
Medscape

Prediction of Cytochrome P450 Isoform Responsible for Metabolizing a Drug Molecule

The main dataset consists of total 216 substrates which can be metabolized by one of the five CYP isoforms used in this study. This dataset have 111, 47, 29, 20 and 19 molecules metabolized through ...
GEN

CYP Tool for Induction and Inhibition Studies

The cytochromes P450 (CYPs) are the main enzyme family for metabolism of therapeutic drugs. CYP3A4 is the most active drug metabolizing CYP, and it plays a prominent role in adverse drug-drug ...
ascopubs.org

An evaluation of the drug interaction potential of netupitant with substrates, inhibitor and inducer of CYP3A4.

The estimation of life-time for the patients who acquired resistance to standard chemotherapies. This is an ASCO Meeting Abstract from the 2012 ASCO Annual Meeting I. This abstract does not include a ...
technologynetworks

Kinetic Constants and Sample-to-Sample Variation in the Rate of Metabolism of two or more Substrates for Human Liver Microsomal CYP1A2, CYP2B6, CYP2C8, CYP2D6 and CYP3A4/5

Marker substrates for certain CYPs have changed for several reasons, including the need for improved selectivity and sensitivity, reliable substrates for LC/MS/MS analysis, and substrates that provide ...
Medscape

Prediction of Cytochrome P450 Isoform Responsible for Metabolizing a Drug Molecule

BMC Pharmacol. 2010;10(8):1-9. We have created an independent dataset in order to evaluate performance without any bias. For this, we downloaded from DrugBank 146 molecules that were reported to be ...