The results of a newly reported study may offer scientists a strategy for mitigating the negative side effects associated with intravenous injection of nanoparticles used in medicine. The new approach ...
The complement system serves many biological functions, including the eradication of invasive pathogens and the removal of damaged cells and immune-complexes. Uncontrolled complement activation causes ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, No. 24 (Jun. 15, 2004), pp. 8924-8929 (6 pages) Vaccinia virus complement control protein (VCP), a homolog of ...
The complement system is necessary for the induction of optimal T-cell effector function. In complement component 3 (C3)-deficient mice, CD4 + T-cell responses to viruses are impaired and the optimal ...
-- Poster presentation to highlight data from completed first-in-human, Phase 1 ascending dose clinical trial of ADX-097 in healthy volunteers; results support Phase 2 dose selection and continued ...
TSP-1 reduced C3 and C5 cleavage and formation of the membrane attack complex, attenuating complement-mediated injury in AAV models. Complement activation is a relevant driver in the pathomechanisms ...
Initial study data indicate GEM103 can regulate complement activity in geographic atrophy secondary to dry age-related macular degeneration and has a tolerable safety profile, according to a press ...
The complement system has an important role in neuroinflammation, both in the pathogenesis of Alzheimer’s disease and in the most severe infections affecting the central nervous system such as ...
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