About one-third of all drugs approved by the Food and Drug Administration target the largest family of cell membrane receptors called G protein-coupled receptors (GPCRs). GPCRs are indispensable for ...

Unexpected behaviours in G proteins could be exploited to design next-generation opioid drugs that provide stronger, longer-lasting pain relief. G proteins are the molecular machines that link ...

For decades, dopamine signaling was viewed primarily through the lens of motor vigor—how fast or forcefully one moves. However, a landmark 2025 study from Karolinska Institutet published in Nature ...

Understanding what causes a compound to be a biased modulator is a key step in enabling the design of compounds with more precision in the array of G proteins that they activate. The scientists ...

New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, ...

Opioid receptors are fantastic targets for treating pain—but unfortunately, the drugs that target them can be addictive. Because the molecules suppress breathing and heart function, those drugs can ...

The 5th GPCRs-Targeted Drug Discovery Summit is a focused forum spotlighting the renaissance of GPCR-targeted therapeutics. This event guide explores novel screening platforms, structural biology ...

G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...

G protein-coupled receptors (GPCRs) act as the body’s universal translators, converting external signals into specific cellular actions. They influence senses, heart function, mood, and immune ...

Researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel drug ...