Cellular senescence, a state characterized by stable cell cycle arrest, has emerged as a critical process in maintaining tissue homeostasis by limiting the ...

Within aging organisms, cells slowly lose their youthful precision: Membranes stiffen, repair systems malfunction, and proteins begin to misfold and pile up. One of the cell organelles that ...

A study of killifish reveals how protein dysfunction develops in vertebrate brain cells, a key driver of aging. Aging and neurodegeneration are both known to disrupt the production of functional ...

There's new research behind aging.

Scientists have identified a critical breakdown in the cellular machinery that produces proteins in aging brains.

Aging and neurodegeneration are both known to disrupt the production of functional proteins in cells – a process called "proteostasis," or protein homeostasis. Brain cells in particular fall prey to ...

Toward the goal of elucidating endocrine system aging mechanisms, this study establishes the first single-cell aging atlas across multiple endocrine organs. The research reveals conserved aging ...

With aging, the intestine gradually loses its ability to regenerate after damage. An international research team involving the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) in Jena and ...

"This collection is published in memory of Professor Judith Campisi, a pioneering force in the field of cellular senescence whose groundbreaking work shaped the understanding of senescence in aging, ...