Just a decade ago, experimental work by Guerrier, Flayeux, and Boschetti demonstrated the ability of sodium chloride (NaCl) gradients on hydroxyapatite (HA) to remove aggregates from IgG preparations.
Several chromatographic resins are available for downstream purification. Monoclonal antibodies (mAbs) are a successful class of therapeutic products used increasingly in the past 15-20 years, but the ...
Producing novel antibody variants, including multi-specifics and even some traditional monoclonal antibodies (mAbs), can result in high levels of product-related impurities, including aggregates.
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