One of the main proteins that contributes to Alzheimer's disease is called phospho-tau (p-tau). When p-tau gets too many phosphate groups attached to it (a process called hyperphosphorylation), it ...

Conventional small-molecule drugs for reducing pTau include phosphatase activators of PP2A, and kinase inhibitors of GSK3β, CDK5, etc., as well as active or passive immunotherapies targeting pTau.

Recent studies suggest that when neurons are overwhelmed by oxidative stress, they spew out toxic, peroxidated lipids. Glia then sail in to mop up the spill, containing the oils within intracellular ...

Hyperphosphorylated tau, the protein that makes up the tangles observed in tauopathies like Alzheimer’s disease, may be the consequence of an antiviral mechanism intended to protect the brain from ...

Tau tangles are a hallmark of Alzheimer's disease and related disorders, but evidence suggests the real damage may come from ...

Tubulin-associated unit (tau) has been widely studied for its role in neurodegeneration since it was first isolated from the porcine brain in 1975. 1 Under normal conditions, tau mainly localizes to ...

Besides memory loss, many people with AD also lose their sensitivity to touch. A new study attributes this to a surprising source: neurofibrillary tangles within the spinal cord. In Nature ...