Cell-directed changes in the ligand-binding affinity ('activation') of integrins regulate cell adhesion and migration, extracellular matrix assembly and mechanotransduction. The final intracellular ...
Integrins are transmembrane adhesion receptors that coordinate cellular responses with the extracellular environment. Integrin function is especially important in neutrophils and macrophages, key ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, No. 26 (Dec. 24, 2002), pp. 16737-16741 (5 pages) Conformational movement of the C-terminal α7 helix in the ...
Integrins are heterodimer transmembrane receptors for the extracellular matrix composed of an alpha and beta subunit. Natural integrin ligands include laminin, fibronectin, and vitronectin, but they ...
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