It's the ugly duckling story of the molecular world. Intein, thought two decades ago to be nothing more than a molecular parasite or a harmless hitchhiker, is today an invaluable tool in the ...

Inteins are parasitic genetic elements that excise themselves at the protein level by self-splicing, allowing the formation of functional, nondisrupted proteins. Many inteins contain a homing ...

The SCN1A gene is too large to fit into aconventional viral delivery systems. Scientists overcame this hurdle with a pioneering "split-intein" mechanism, which is like two separate trucks, delivering ...

At the recently concluded ARVO meeting, Splicebio S.L. presented the first preclinical results on the company’s new candidate, SB-007, for the treatment of Stargardt disease, a rare genetic disease ...

Why do problems occur with a special variant of 'protein glues', the split inteins, that severely limit their use in producing proteins? A team has now answered this question. Proteins are the ...

The ability to site-selectively incorporate a synthetic moiety like a biophysical probe, an unnatural amino acid, or a defined posttranslational modification into a protein of interest opens up a ...

Proteins are fundamental building blocks of life, composed of folded peptide chains formed by sequences of amino acids. They perform a wide range of functions, from maintaining cellular structures to ...

Proteins are the building blocks of life. They consist of folded peptide chains, which in turn are made up of a series of amino acids. From stabilizing cell structure to catalyzing chemical reactions, ...

Long-standing problem solved: Researchers discover that misfolding prevents efficient utilisation of so-called split inteins as ‘protein glue’ Proteins are the building blocks of life. They consist of ...

Proteins are the building blocks of life. They consist of folded peptide chains, which in turn are made up of a series of amino acids. From stabilising cell structure to catalysing chemical reactions, ...