Human organoids are 3D cell cultures derived from adult stem cells and maintain the variable distribution of epithelial cells seen in primary tissue. They can recapitulate the mechanisms of epithelial ...

Although the gut renews itself constantly, its stem cells accumulate age-related molecular changes that quietly alter how ...

Tuft cells are present throughout the intestinal tract as well as in many organs. Studies in mice have shown that when tuft cells sense the presence of pathogens, they signal to immune cells and to ...

Scientists have uncovered a gut-specific epigenetic aging mechanism that links inflammation and iron imbalance to cancer risk and may be reversible.

The intestinal epithelium undergoes rapid renewal every 3–5 days, a process driven by intestinal stem cells (ISCs) located at ...

Imagine if your gut could heal itself-even after years of wear and tear. Scientists at Cold Spring Harbor Laboratory (CSHL) ...

The human gut replaces its cells faster than any other tissue in the body. Every few days, fresh cells are produced by specialized stem cells that ...

The terms "intestinal barrier" and "intestinal permeability" describe two different aspects of the same anatomical structure, the intestinal wall composed of four layers, the mucosa, the submucosa, ...