Nature

Cleavage of Fyn and Lyn in their N-terminal unique regions during induction of apoptosis: a new mechanism for Src kinase regulation

The Src family of non receptor protein tyrosine kinases consists of nine members (Src, Lyn, Fyn, Lck, Hck, Fgr, Blk, Yes and Yrk) that are believed to play important roles in a variety of cellular ...
EurekAlert!

Src heterodimerically activates Lyn or Fyn to serve as targets for esophageal squamous cell carcinoma (ESCC) diagnosis and treatment

The study was led by Professor Qimin Zhan (Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Molecular Oncology, Peking University Cancer ...
Nature

Balancing immunoreceptor signalling

The Src-family kinases LYN and FYN differentially regulate immunoreceptor signalling by directing the phosphorylation of SH2 domain-containing protein tyrosine phosphatase 1 (SHP1, also known as PTPN6 ...
EurekAlert!

Proposed Model of ponatinib-mediated disruption of intratumoral Src/Lyn or /Fyn heterodimers. (IMAGE)

Ponatinib disrupts the interaction between intratumoral Src with Lyn or Fyn to inhibit the phosphorylation of these two SFKs, and resultantly inhibits tumor malignancy. However, Src cannot interact ...