MLL1 complex is required for transcriptional activation and for the maintenance of stem and progenitor cells in Acute myeloid leukemia (AML). Targeting the MLL1 complex could be a new approach to ...

Acute myeloid leukemia (AML) is the most common form of acute leukemia. It is characterized by an increase of malignant myeloid progenitor cells at the expense of mature blood cells. Only twenty-five ...

Acute myeloid leukemia (AML) is the most common form of acute leukemia. It is characterized by an increase of malignant myeloid progenitor cells at the expense of mature blood cells. Only twenty-five ...

MLL1 is rearranged in patients with acute leukaemia and leads to the deregulated expression of HOX genes, among other changes. MLL1 interacts with a wide variety of proteins, and four recent papers ...

Researchers at the Vetmeduni Vienna and the Ludwig Boltzmann Institute for Cancer Research have identified a new therapeutic strategy for Acute Myeloid Leukemia (AML), the most common form of acute ...