For decades, oncologists have watched a frustrating pattern repeat itself. Tumors fueled by the MYC protein, one of the most commonly hijacked genes in human cancer, often shrug off the very ...

Novel Treatment Targets in Sarcoma: More Than Just the GIST MYC has proven to be a highly potent oncoprotein when it is overexpressed, but is also a pleiotropic transcription factor essential for ...

Efforts to develop effective therapies for MYC-amplified Group 3 medulloblastoma (G3-MB) are hindered by an incomplete understanding of how MYC expression is controlled in these tumors. MYC, an ...

The MYC oncogene family plays an important role in neoplastic disease, and has been extensively studied over decades. Evidence showing the N-terminal and C-terminal regions of MYC can function as a ...

MYC family genes are essential for the human organism. According to current knowledge, they regulate the expression of most cellular genes. Misregulation of MYC proteins significantly contributes to ...

The Myc family of transcription factors, including Myc, N-Myc, and L-Myc, bind DNA at specific sequences and regulate gene expression by binding to enhancer-box (E-Box) sequences via dimerization with ...

If you ask me, one of the cooler aspects of science has to do with the larger research narratives that laboratories produce—sure, an individual study can detail a surprising result or provide a ...

Researchers have shown that c-MYC is an oncogene that drives neuroblastoma in some high-risk patients. Researchers have identified mechanisms that drive about 10 percent of high-risk neuroblastoma ...

18F-fluorothymidine (FLT) PET-CT for early response assessment in advanced pancreatic cancer. This is an ASCO Meeting Abstract from the 2012 ASCO Annual Meeting I. This abstract does not include a ...