Scientists discovered that lowering a specific molecule helps microglia switch into a protective state that quiets brain inflammation in Alzheimer’s. A small group of these cells seems to have an ...

In tauopathies, scientists tend to focus on neuronal tau. They track its pathology and blame it for dysfunctional microglia. Now, researchers led by Celeste Karch at Washington University, St. Louis, ...

Alzheimer's disease (AD) is a highly debilitating neurodegenerative disease characterized by the progressive loss of memory and decline of mental functions. Earlier research has uncovered some of the ...

Microglia respond to proteinopathies by changing their shapes and expression profiles in different ways. Here’s one that has been somewhat overlooked: rod-shaped microglia. These long, straight cells ...

Microglia, the primary immune cells in the brain, play vital roles in neurogenesis, homeostasis maintenance, synaptic plasticity, and brain development. They are widely used in monoculture for ...

Examining post-mortem tissue from the brains of people with Alzheimer's disease, Stanford University School of Medicine investigators identified what appear to be iron-containing microglia -- ...

Tiny immune cells called microglia protect the central nervous system (CNS) in a multitude of ways: They provide innate immunity, shape neurodevelopment, maintain homeostasis and modulate neurological ...

While amyloid β plaques are hallmarks of Alzheimer’s disease (AD), recent research suggests that they aren’t the only players in the neurodegenerative disorder. Genome-wide association studies and RNA ...

As you read this sentence, an army of cells patrols your brain. These soldiers slip around neurons, using their gangly appendages to search for threats. If one of them detects a pathogen or injury, it ...

It’s hard to overstate how crucial microglia are to brain health. These humble immune cells quietly patrol the central nervous system, clearing debris, pruning synapses, and maintaining myelin. But ...