NK cell-related immunotherapeutics, such as tumor-specific monoclonal antibodies (mAbs) to elicit NK cell-mediated ADCC against tumor cells, are being developed for the treatment of cancers. As an ...
Therapeutic antibodies are now the major class of successful protein drugs with many more in development to target a variety of major diseases. An important and desirable biological activity of most ...
Mechanism of chemoresistance to 5-fluorouracil mediated by miR-192/miR-215 in colon cancer cell lines: Cell-cycle effects and post-transcriptional thymidilate synthase regulation. Use of plasma ...
SAN DIEGO--(BUSINESS WIRE)--Artiva Biotherapeutics, Inc., a clinical stage company whose mission is to deliver highly effective, off-the-shelf, allogeneic natural killer (NK) cell-based therapies that ...
MADISON, Wis.--(BUSINESS WIRE)--Drug developers have a new bioluminescent tool to characterize how potential pharmaceuticals behave in biologically relevant systems. A new primary cell bioassay from ...
Association of Aurora kinase A and epidermal growth factor receptor (EGFR) gene copy number with overall survival in KRAS wild-type patients with metastatic colorectal cancer. Background: Prognosis ...
When a virus invades an individual, both innate and adaptive immunity play crucial roles. The successful viral pathogens can antagonize these immune pathways with genes that inhibit the key players in ...
As cancer progresses, NK cells express lower levels of activating receptors and are functionally suppressed by tumor microenvironment. The progression of breast cancer is associated with mechanisms ...
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