One of the hallmarks of Alzheimer's disease is the clumping of proteins called Tau, which form tangled fibrils in the brain.

MIT chemists used NMR spectroscopy to reveal the disordered “fuzzy coat” surrounding Tau protein fibrils, offering new ...

Macromolecular crowding is a central concept in understanding how proteins function in the dense and heterogeneous intracellular environment. In crowded cellular conditions, high concentrations of ...

High-pressure nuclear magnetic resonance (NMR) spectroscopy has emerged as a critical technique for investigating the structural dynamics of proteins under extreme conditions. By subjecting biological ...

Predicting protein structures from the amino acid sequences helps scientists to understand how proteins interact with other molecules, which is crucial for developing new drugs and therapies.