Scientists from the National University of Singapore (NUS) have developed a biochemical technique that captures fleeting ...

A new research paper was published in Volume 16 of Oncotarget on August 29, 2025, titled "In vivo manipulation of the protein homeostasis network in rhabdomyosarcoma." In this study led by first ...

A new study led by Pierre Close's team (GIGA, Laboratory of Cancer Signaling, and WELRI Investigator) reveals how subtly ...

Membrane protein transport and quality control are central to yeast cell homeostasis, ensuring that proteins reach their correct cellular destinations while aberrant or damaged proteins are ...

Protein quality control research is “almost exclusively focused on heat shock proteins, which are ubiquitously present” up and down the evolutionary chain, Xiaolu Yang told BioWorld. But “for more ...

Anyone who's tried to neatly gather a fitted sheet can tell you: folding is hard. Get it wrong with your laundry and the result can be a crumpled, wrinkled mess of fabric, but when folding fails among ...

Researchers have discovered the first protein quality control system in the yeast nucleus. They report that the system involves an ubiquitin-protein ligase that specifically targets four distinct ...

“Together, these findings confirm that proteostasis inhibition can slow RMS growth and suggest that targeting compensatory network components might yield synergistic outcomes” “Together, these ...

When it comes to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and certain forms of dementia, researchers have known that protein quality control and damage to the nuclear ...

Researchers have identified a backup mechanism of protein quality control which prevents the toxic effects of protein aggregation in specific tissues when normal methods of molecular monitoring fail.