Within the family of cell membrane lipids known as phosphoinositides and the kinase enzymes that regulate them, phosphoinositide 3-kinases (PI3Ks) have been cast in a starring role as scientists study ...

A research team maps the key tasks that define modern enzyme engineering—function annotation, structure modeling, and property prediction—and explain how AI methods now accelerate each step, from ...

MADISON, Wis. -- Scientists have long known that the protein p53, when mutated, is a critical factor in the onset of many different kinds of cancer. In its unmutated form, however, it is known to ...

A research team presents an overview of recent advances in the microbial biosynthesis of L-tryptophan (L-Trp) and its ...

NUDT5 enzyme acts as a molecular scaffold that maintains metabolic balance. Inside every cell, a finely tuned metabolic network determines when to build, recycle or stop producing essential molecules.

This review synthesizes progress in pathway optimization, regulatory rewiring, and microbial cell factory design that has ...

Cells spend energy not just on reactions, but on control. New research explains why staying stable comes with an unseen ...

Enzymes are biological catalysts that speed up chemical reactions in living organisms. They are essential for life, as they play a crucial role in various biological processes, such as digestion, ...

On Oct. 10, the Schroeder Lab, led by Prof. Frank Schroeder, chemistry and chemical biology, published a study detailing a new class of serotonin-containing compounds and another serotonin pathway in ...

The 8-Bromo-cAMP sodium salt PKA activator, a synthetic analog of cAMP, is one of the most potent tools of investigating and playing with this pathway, which has become an essential part of ...