This news release is available in German. Whenever muscles contract, so-called ryanodine receptors come into play. Calcium ions, which are ultimately responsible for the contraction of muscle cells, ...

Overzealous calcium signaling and dysfunctional protein degradation occur early in Alzheimer’s disease pathogenesis. Now, new evidence links the two. Two recent papers support the hypothesis that, ...

S5 mutations disrupt RyR1 channel function, influencing both channel activity and gating mechanisms. This impacts the release of calcium and affects muscle contractions, leading to severe muscle ...

The type 1 ryanodine receptor (RyR1) is an important calcium release channel in skeletal muscles essential for muscle contraction. It mediates calcium release from the sarcoplasmic reticulum, a ...

Statins are a cornerstone of heart health, but muscle pain and weakness cause many patients to quit taking them. Scientists have now identified the precise molecular trigger behind these side effects.

The hearts of men and women have remarkable differences in terms of their function in health and the heart diseases that impact them. In particular, there is a major difference between prevalent heart ...