Sequential conditional probability ratio tests (SCPRTs) provide monitoring procedures with a unique property that a decision reached at early stopping is unlikely to be reversed should the trial ...

The customary approach to early-phase clinical trial design, where the focus is on identification of the maximum tolerated dose, is not always suitable for noncytotoxic or other targeted therapies.

When designing programs or software for the implementation of Monte Carlo (MC) hypothesis tests, we can save computation time by using sequential stopping boundaries. Such boundaries imply stopping ...

A genome-wide association study ascertains through genome, potential genetic associations between genetic polymorphism and observable traits or disease. 1, 2 Recent advances in DNA technology made it ...

Yan Zhuang specializes in the areas of sequential analysis, sampling strategies, sample size determination, and statistical inference. She also enjoys working with people from other disciplines to ...

PROC SURVEYSELECT provides a variety of methods for selecting probability-based random samples. With probability sampling, each unit in the survey population has a known, positive probablity of ...