MPA-CF 3 specifically binds to COPZ1, a subunit of COPI. Upon binding, MPA-CF 3 destabilizes COPZ1 and disrupts the interaction of COPZ1 with the EV-A71 2C protein in a concentration-dependent manner.
This new article publication from Acta Pharmaceutica Sinica B, discusses the identification of novel small-molecule inhibitors of SARS-CoV-2 by chemical genetics. There are only eight approved small ...
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