The processes of DNA replication and transcription may introduce torsional (or twisting) strains in the DNA structure. These topological problems are relieved by an enzyme called topoisomerase II ...
A new study conducted by scientists at the University of Sheffield in collaboration with researchers from UT Southwestern ...
Doxorubicin, a 50-year-old chemotherapy drug still in widespread use against a variety of cancers, has long been known to destroy heart tissue, as well as tumors, in some patients. Scientists have now ...
New research published in Nature Communications has linked a normal cellular process to an accumulation of DNA mutations in cancer and identified cancer-driving mutations in an underexplored part of ...
In autistic patients, a heterozygous germline mutation was identified in the ATPase domain of TOP2B. Germline mutations are mutations in a reproductive cell that is later reflected in every cell of ...
Researchers from the Cleveland Clinic identified a new mechanism of AIC involving upregulated TOP2B expression and directly impacting cardiomyocyte function without the formation of ...
A series of experiments reveal that a germline mutation of the enzyme topoisomerase II B affects the movement of proteins in the nuclei of cells with this mutation The processes of DNA replication and ...
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