Figure 1: Application of RNAplfold to separate functional from nonfunctional siRNAs. Because it was previously claimed that regions of low G/C content coincide with efficient siRNA silencing 14 and ...

Sigma-Aldrich has announced that it has entered an exclusive arrangement with Rosetta Inpharmatics LLC to access the company's proprietary and patent pending bioinformatics design tools for siRNA ...

RNA interference using small interfering RNAs (siRNAs) has become a mainstay of functional gene characterization and has generated over a dozen FDA-approved therapeutics and drugs in late-stage ...

When performing RNAi experiments using siRNAduplexes, the first critical challenge is the design ofefficient siRNA. Recent studies concerning the importanceof mRNA accessibility in relation to the ...

This is an introduction to the biological mechanism of RNA interference (RNAi) and experimental application of short, interfering RNA (siRNA). The key steps of the endogenous RNAi pathway will be ...

Small synthetic fragments of genetic material called small interfering RNA (siRNA) can block production of abnormal proteins; however, these exciting new drug candidates can also induce a strong ...

RNAi: Five Tips to Better Silencing - Table 4: Selected Online siRNA-Design Tools ...

The distribution of glycans on a monoclonal antibody impacts its function and half-life. Earlier this month, Masue Marbiah, PhD, a postdoctoral researcher at Imperial College London who develops ...

“The copious patentable aspects of a therapeutically efficacious siRNA delivery formulation imply intense patenting activity in the years to come, along with market exclusivity that can be extended ...

New Transfection Systems Tackle Delivery Issues and Off-Target Effects Will RNAi-based therapeutics provide the next class of blockbuster drugs? If pharma’s acquisition spree of companies with ...

New drug candidates called small interfering RNA (siRNA) can not only block production of abnormal proteins, but also induce a strong immune response, causing toxic side effects. Understanding how ...