Cell signalling pathways are central to maintaining cellular homeostasis and regulating essential functions such as proliferation, apoptosis, and repair. In both cancer and neurodegenerative diseases, ...

As part of the body's first line of defense against foreign invaders, macrophages play an integral role in the innate immune ...

Researchers have identified an unexpected mechanism that links age-related stress to the decline of blood-forming stem cells. Instead of triggering cell death, a known signaling pathway subtly ...

A team led by Mount Sinai researchers has identified stem cell populations and mechanisms underlying age-related degeneration in glands that are vital to eye function. The findings, published in ...

A hallmark of type 2 diabetes is the progressive loss of beta cell mass: cells in the pancreas that produce and release ...

The researchers used lipid nanoparticles (LNPs) to deliver cyclic GMP-AMP (cGAMP) synthase (cGAS) mRNA to cancer cells. This results in production of the endogenous stimulator of interferon genes ...

A key molecular dynamic could be the key to fighting tumors while allowing patients to still receive life-saving cell ...

A newly discovered type of liver cell may hold clues for treating severe liver disease, according to a recent study from the University of Michigan Life Sciences Institute. The findings, published in ...

• BTK inhibitors work by targeting and blocking the BTK enzyme, which is crucial for the survival and growth of cancerous B-cells in mantle cell lymphoma (MCL). This cuts off the cancer cell’s support ...

The immune system is a complex response of various cells that detect and elicit mechanisms to eliminate disease. This ...

A recent mouse model based study suggests that blocking TGF-β may improve osteoporosis treatment by helping quiescent osteoblasts in inactive bone surfaces return to an active state. Using spatial ...