A tiny antibody component could fundamentally transform the treatment of cystic fibrosis: For the first time, researchers ...

Bacterial sensors usually rely on emitting light to transfer information about what they're sensing, but that method isn't ...

When most people think about insulin resistance, sugar is usually the first thing that comes to mind. And while excessive ...

Cell-based assay innovation is reshaping how we discover, validate, and de-risk therapeutic candidates across disease areas. This Research Topic invites ...

This important paper substantially advances our understanding of how Molidustat may work, beyond its canonical role, by identifying its therapeutic targets in cancer. This study presents a compelling ...

Mitochondria are increasingly recognized as dynamic signaling hubs that influence cell fate not only through bioenergetics, but also through exchange of ...

As we age, our cells don’t just wear down—they reorganize. Researchers found that cells actively remodel a key structure called the endoplasmic reticulum, reducing protein-producing regions while ...

T cell activation—the process by which these key immune defenders recognize threats and mobilize against them—depends on exquisitely timed molecular signals. Now researchers have captured one of the ...

Extreme heatwaves aren’t just a seasonal inconvenience anymore. They’re longer, hotter, and deadlier than ever before. Billions of people around the world feel their effects, which can range from ...

Innate immune sensors – known as pattern recognition receptors (PRRs) – detect specific molecular components of bacterial or viral intruders. The PRRs forward the signals which results in the ...

New experiments reveal how astrocytes tune neuronal activity to modulate our mental and emotional states. The results suggest that neuron-only brain models, such as connectomes, leave out a crucial ...

This important work combines theoretical analysis with precise experimental perturbation to demonstrate that the Wnt signaling pathway is characterized by anti-resonance, or a suppression of pathway ...