GV-971 reportedly also reduced brain Aβ burden, tau hyperphosphorylation, and cognitive deficits in these mice. This paper was subsequently challenged as a matter arising in the same journal (Rao, …

Tsuda Y, Ugai H, Wunderlich G, Shin JG. Pharmacokinetics of Single Doses of BI 425809 in Healthy Chinese and Japanese Subjects: A Randomized Study. Clin Ther. 2019 May;41 (5):961-971. Epub …

Nov 25, 2015 · AD Target / Therapy Types The two tables below organize the therapeutics within this database by therapy type and proposed target type. The number of therapeutics within each …

Search By Attributes Phase 0 Phase 1 Phase 1/2 Phase 2 Phase 2/3 Phase 3 Phase 4 Approved Rejected Inactive Discontinued Not Regulated Withdrawn Target Type Keyword 442 Therapeutics …

Aug 31, 2018 · APP+PS1 transgenic rats express human APP with the Swedish and Indiana mutations and human PSEN1 with the L166P mutation. Both transgenes are driven by the ubiquitin-C …

Clin Ther. 2019 May;41 (5):961-971. Epub 2019 Apr 17 PubMed. Wunderlich G, Blahova Z, Garcia M, Jessen F. Efficacy and safety of the novel GlyT1 inhibitor BI 425809 in Alzheimer's dementia: a …

Jul 8, 2021 · The words "mushroom" and "stub" denote two types of dendritic spines, but while their shapes are easy to behold, whatever biochemical differences hide within is a mystery. To explore …

Jul 27, 2018 · Under hyperosmotic stress, FUS builds up in cytoplasmic stress granules in neurons. Mislocalization of transportins, which escort FUS into the nucleus, may be to blame. The findings …

Nov 10, 2011 · Despite almost two decades of research, it is not yet clear how hormone replacement therapy affects a woman’s risk of getting Alzheimer’s disease. The curators of the AlzRisk database, …

Jun 12, 2017 · The spread of Alzheimer’s disease pathology has puzzled researchers for decades. Autopsies show that amyloid plaques and neurofibrillary tangles accumulate in distinct locations …