Brain Changes Speak Volumes About Normal Aging and Dementia
Jun 7, 2013 · Brain atrophy plagues more than just people with neurodegenerative disorders. Even seemingly healthy individuals lose brain matter over time. Can doctors and researchers separate …
Accelerated Brain Volume Loss Caused by Anti-β-Amyloid Drugs: A ...
Apr 4, 2023 · Clinicians have often associated focal or generalized cerebral atrophy seen on imaging studies with loss of brain tissue, or loss of specific cell types, due to injury or degeneration.
Brain Atrophy Patterns Support Distinct Subtypes of ... - ALZFORUM
Aug 3, 2016 · The regions of the brain affected by the disease vary significantly as well. Multiple imaging studies have identified various patterns of atrophy, white-matter damage, and waning neural activity …
What About the Brain Shrinkage Seen with Aβ Removal?
Apr 3, 2023 · In general, brain atrophy is considered a marker for neurodegeneration, including in the A/T/N biomarker classification system for Alzheimer’s disease. The Alzheimer’s Association/NIA draft …
FDA Approves BrainSee, AI Software That Purportedly Predicts AD
Jan 19, 2024 · Years before brain atrophy due to Alzheimer’s disease becomes blatantly obvious on an MRI scan, neurons start to die off in specific regions of the brain. Researchers have long proposed …
Do Frontoparietal Regions Shrink First in Preclinical Alzheimer’s?
May 2, 2014 · Atrophy heat map: Frontoparietal areas of the brain atrophy faster (red) in people with falling CSF Ab than in those with stable Aβ levels, while temporal regions deteriorate at about the …
Is the ‘Atrophy’ of Immunotherapy Just the Dismantling ... - ALZFORUM
Aug 28, 2024 · The brain shrinkage seen on amyloid immunotherapy remains an unsolved and concerning riddle. At the Alzheimer’s Association International Conference, held July 27 to August 1 …
Infiltrating CD8+ T cells exacerbate Alzheimer's disease ... - ALZFORUM
Sep 1, 2023 · Inhibition of IFNγ significantly ameliorated brain atrophy (Chen et al., 2023). It is interesting to investigate if blocking IFNγ receptors in specific cells, including microglia, would …
Plasma p-Tau217 Flags Alzheimer’s Pathology in Other Disorders
Feb 23, 2025 · Plasma p-Tau217 concentrations of 0.125 pg/mL or higher provided the optimum cutoff for distinguishing AD pathology, the authors found. Distinct Atrophy Patterns. In FTD, some brain …
Trontinemab Fuels Hope for Brain Shuttle Lift-Off | ALZFORUM
May 1, 2025 · According to work by Nick Fox of University College London, so-called “pseudo-atrophy” might be accounted for by removal of plaques along with their “suburban sprawl” of other proteins, …