p53, also known as tumor protein p53, TP53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is often …

This is a heavily studied pathway in cancer biology and oncology with a history that dates back to 1979 when p53 was discovered. The p53 pathway is a complex cellular stress response network with …

Dec 19, 2025 · What is TP53 and what role does it play in cancer? The TP53 gene helps prevent cancer by repairing DNA or causing cell death when DNA is too damaged. Mutations in the TP53 gene are …

Jun 15, 2025 · At the heart of this defense is a protein known as p53, often called the “guardian of the genome.” This protein is a component of a pathway that responds to cellular stress, working to keep …

The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing …

Apr 9, 2025 · This Review discusses the roles, mechanisms and physiological settings in which NACDs are regulated by p53, and their potential targeting for the treatment of human diseases.

The perturbation of p53 signaling pathways is required for the development of most cancers; however, it is now becoming clear that p53 has a much broader role in human health and diseases.

Dec 29, 2025 · This study associates p53 loss and brain metastasis in breast cancer. Mechanistically, p53-null tumors recruit astrocytes that provide substrates for enhanced fatty acid synthesis via …

Apr 29, 2025 · Explore the p53 signaling pathway, its regulatory mechanisms, and its role in maintaining cellular integrity and response to stress.

Jan 1, 2025 · We propose a model for how DNA binding by p53 is regulated by its disordered regions. Defects in the tumor suppressor protein p53 are found in the majority of cancers.