1 day ago · 49ers vs. Colts live updates, highlights from 'Monday Night Football' Final: 49ers 48, Colts 27 11:19 p.m.: Purdy has come in to kneel out the clock, and the 49ers have a huge win.

5 hours ago · 49ers take control, get a pick 6 on Philip Rivers The Colts eventually faded Monday night after a good start, which sums up their season as a whole.

1 day ago · The San Francisco 49ers finished their Week 16 "Monday Night Football" contest with a 48-27 win over the Indianapolis Colts at Lucas Oil Stadium.

1 day ago · What to Know The San Francisco 49ers (11-4) thumped the Indianapolis Colts (8-7) with a 48-27 victory on "Monday Night Football" in Week 16 at Lucas Oil Stadium. Brock Purdy dazzled in …

1 day ago · The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy’s career-high five touchdown passes. Christian McCaffrey racked up …

1 day ago · A meeting featuring two of the NFL's best in Christian McCaffrey and Jonathan Taylor will close Week 16 as the 49ers and Colts clash in a matchup with playoff implications.

1 day ago · Here's what to know from the 49ers' win over the Colts on Monday night.

2 days ago · The San Francisco 49ers got past Philip Rivers and the Indianapolis Colts 48-27 on Monday Night Football. Here are winners and losers.

1 day ago · Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats and more for Colts-49ers.

1 day ago · Brock Purdy, who threw a career-high five touchdowns, and the 49ers pulled away from the Colts on Monday night for a 48-27 win.