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Some Staphylococcus species (especially Staph. aureus and MRSA) appear sensitive to clindamycin on routine testing, but actually become resistant during therapy. This failure happens due to inducible clindamycin resistance. The problem is caused by erm genes. This enzyme methylates 23S rRNA on the 50S ribosome → the antibiotic can no longer bind to the target site. | Elmicrobiologist
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